Nepal leg spinner Sandeep Lamichhane was wrecker-in-chief, taking six for 16 as the American side were finished off in 12 overs in the World Cup league two match in Kathmandu.
West Indies-born opener Xavier Marshall was the only US batsman to get into double figures, making 16. Spinner Sushan Bhari took the other four wickets for just five runs.
Timil Patel hit a four, a six and a four of straight balls to complete the rout by eight wickets.
Zimbabwe were also bowled out for 35 by Sri Lanka in April 2004 at Harare.